What is ProtEx-MND?
ProtEx-MND is investigating whether exercise can slow down the progression of Motor Neurone Disease (MND). The aim is to explore the neuroprotective effects of a 16 week structures exercise [program on the brain, spinal cord and muscles of people living with MND. The participants will be randomly assigned to one of two groups.
Train Group: Participates in 3 supervised exercise training sessions per week for 16 weeks at the Victoria University Clinical Exercise and rehabilitation (VUCER) clinic, or a gym local to you.
Control group: Continues with their usual standard of care, without added exercise.
Participants in both groups will undergo detailed assessments at three time points: Before the intervention, after 16 weeks and at 24 weeks. (8 week after stopped exercise).
Eligibility Criteria
Age: 18-80 y
Diagnosis of definite or probable (laboratory-supported) MND
Onset of MND less than or equal to 36 months before screening
ALSFRS-R score greater than or equal to 24
Forced Vital Capacity greater than or equal to 60 % of predicted
Patients able to understand and comply with the requirements of the entire study
Exclusion Criteria
Any medical disorder that would make physical activity contraindicated, including active malignancy, and severe heart, lung, renal, or liver failure
Contraindications to have MRI (e.g., implanted metal, severe claustrophobia
Participation in pharmacological studies within the 30 days prior to screening
VIC | Victoria University | Alessandra Ferri |
Want to know more?
For more information Visit The ‘ProtEx-MND’ project | Victoria University